Wednesday, 24 June 2015

MIndfulness

Right now, mindfulness is a hot topic in psychology and beyond. In 2012, 40 new papers on mindfulness were published every month, a number that has probably risen since. Last September, the Guardian journalist Barney Ronay noted that a staggering 37 new books had been released on the topic that very week. There are numerous conferences devoted to mindfulness around the world, multiple organisations and even dedicated science journals and magazines. And yet, a dissenting voice in this chorus of enthusiasm, a new book out last month – The Buddha Pill: Can Meditation Change You? – warned that mindfulness is not harmless. To bring you up to speed in a jiffy, here we digest the psychology of mindfulness:

What is mindfulness?
With its roots in various philosophical and religious traditions, especially Buddhism, mindfulness is usually defined as paying attention in a non-judgmental way to one's experience of the here and now. Some psychologists' and practitioners' definitions are broader and speak of compassion for and curiosity about the world. The Oxford Mindfulness Centre, affiliated with the University of Oxford, states: "Mindfulness is the awareness that emerges through paying attention on purpose, in the present moment, with compassion, and open-hearted curiosity." A mindful mindset can be adopted deliberately as part of a meditative exercise, but mindfulness is also considered a trait. As a trait, mindfulness is measured by agreement with questionnaire items such as "I intentionally stay aware of my feelings" and disagreement with questionnaire items like "I tend to make judgments about how worthwhile or worthless my experiences are". One popular measure, The Five-Facets Mindfulness Questionnaire measures a person's non-reactivity, their acting with awareness, tendency to be non-judgmental, to be observant, and to describe experiences.

Is mindfulness-based meditation beneficial?
Lots of research certainly suggests it can be, but there are question marks over the rigour of some studies. Case in point: a 2013 study reported that a brief mindfulness intervention increased healthy people's sense of inner peace compared with a control group. But the control group did nothing, so as the researchers acknowledge, " We cannot exactly say whether the significant positive effects in the present study were caused by the mindfulness practice or just by the non-specific support provided by a weekly group."

That said, a review from 2011 of 23 relevant studies reported that mindfulness training could have benefits for people's attentional control and working memory (although the authors warned the quality of the evidence was often poor). Another review, published the same year, of dozens of studies reported that mindfulness has a range of psychological benefits, including reduced anxiety and greater feelings of life having meaning.

A systematic review from 2013 of 8 papers found that mindfulness meditation and similar practices could be beneficial to prison inmates (for example by reducing their anger and hostility), but the authors again warned about the need for higher quality research. Increasingly, aspects of mindfulness meditation are being incorporated into forms of therapy. For instance, a meta-analysis and review from 2012 of controlled trials found that mindfulness-based cognitive therapy successfully helps prevent depression relapse

What about trait mindfulness?

There's evidence that people who are inclined to be mindful tend to have advantages over others who are not. For instance, students who are more mindful have higher self-esteem. And a study from the noughties reported that people who score higher in trait mindfulness tend be more satisfied with their romantic relationships, and respond better to relationship stress. Another paper claimed that managers who are more mindful tend to have higher-performing staff, who are more satisfied with their jobs. There is even evidence that people who are more mindful are less susceptible to the harmful effects of discrimination

How does mindfulness exert its apparent beneficial effects?

Research into this question is ongoing, but a review published in 2011 proposed four key ways: by helping people have more control over their minds, such as the ability to ignore distractions; through increased awareness of one's own body; through improved control over one's own emotions and the ability to cope with unpleasant emotions; and finally, through a changed perspective on the self. Regarding the last component, Britta Hölzel and her colleagues write that: "In place of the identification with the static self, there emerges a tendency to identify with the phenomenon of 'experiencing' itself". This fits the Buddhist teaching that there is no such thing as a permanent unchanging self. The authors go on to say that these four components are highly interrelated and are associated with various neural changes, such as enhanced grey matter in frontal brain areas involved in mental control. 

Mindfulness sounds amazing, is there any reason not to do it?

There's some evidence that mindfulness meditation can be unhelpful or even harmful for some people. A study from the early 90s reported that following a mindfulness-based meditation retreat most meditators described positive benefits, but 17 said they'd had at least one adverse effect, and two described experiencing "profound" adverse effects, such as panic attacks and loss of motivation.

A paper published in 2009 summarises instances of adverse effects documented in 12 published case studies and reviews of mindfulness meditation. The authors place these adverse effects in three categories: mental health (e.g. anxiety, depersonalisation and hallucinations), physical health (e.g. seizures, double vision); and spiritual health (e.g. religious delusions). 

So who could be at risk from these potential adverse effects? Another paper from 2012 warns that little research has been conducted into this question. The authors led by Patricia Dobkin explain why mindfulness might be risky for some vulnerable people: "Meditation, when practiced intently, leads one into deep exploration of ‘inner space.’ Long-held grief, body tension, and critical or judgmental thoughts may be met perhaps for the first time with full attention."


Writing in The Guardian, co-author of The Budha Pill Catherine Wikholm reminds us: "the fact that meditation [including mindfulness-based versions] was primarily designed not to make us happier, but to destroy our sense of individual self – who we feel and think we are most of the time – is often overlooked in the science and media stories about it, which focus almost exclusively on the benefits practitioners can expect."
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--further reading--
A Mindful Moment – a mindfulness-themed trawl of The Psychologist and Research Digest archives.
When Therapy Causes Harm.  
   
Post written by Christian Jarrett (@psych_writer) for the BPS Research Digest.

Sunday, 7 June 2015

What Causes Schizophrenia?


June 4, 2015 | by Justine Alford
Photo credit: lassedesignen/ Shutterstock
Schizophrenia affects 1% of the general population at some stage of their lives, but that figure increases to 10% in individuals who have a close relative with the disorder, such as a parent or sibling. And if you have an identical twin with this mental illness, you have up to a 65% chance of developing it yourself. Needless to say, genetics clearly plays a role in its origins, but scientists have struggled to pinpoint which genes could be responsible for the disease.
Now, after conducting the largest study of its kind, scientists believe they have gathered the most convincing evidence of the DNA alterations that make things go awry in the brain, ultimately leading to the onset of schizophrenia. As described in the journal Neuron, researchers found that a number of schizophrenia-associated gene variations can disrupt the brain’s fragile chemical balance.
The genes in question are involved in preventing neurons from firing out excessive amounts of chemical messengers after stimulation, and thus contribute to inhibitory signaling in the brain. The researchers believe that these mutations therefore allow regions of the brain to become excessively excited, which can be detrimental to cell health if not corrected.
“We’re finally starting to understand what goes wrong in schizophrenia,” lead author Dr. Andrew Pocklington said in a statement. “We now have what we hope is a pretty sizeable piece of the jigsaw puzzle that will help us develop a coherent model of the disease, while helping us to rule out some of the alternatives.”
This research, conducted at Cardiff University, actually builds on prior research by members of the same team that hinted that mutations associated with this mental illness could be interfering with so-called excitatory chemical signaling in the brain. While brain cells need to possess the ability to become excited and fire signals to one another in order to transmit information, there also needs to be a counter system to prevent them from over-firing and ultimately causing cellular damage. This delicate balance of excitatory and inhibitory signaling is therefore pivotal to proper brain functioning.
Although these earlier findings led to the publication of two landmark studies in the prestigious journal Nature, the team now has even more evidence to support the idea that disruption of excitatory signaling in the brain contributes to schizophrenia, rather than being a secondary effect of the disease.
For the investigation, researchers obtained and analyzed genetic data collected from 11,355 schizophrenic patients and 16,416 people without the disorder. More specifically, they were looking for copy number variants (CNVs) within their DNA, which are deletions or gains of large chunks of sequences that result in cells having an abnormal number of copies of certain stretches of DNA.
By comparing CNVs between the two groups, the researchers found that schizophrenic individuals tended to have variations in genes involved in the transmission of a chemical messenger called GABA, which is a major inhibitory neurotransmitter in the brain.
Furthermore, confirming their previous work, they also found that genes involved in the brain’s major excitatory system, mediated by the neurotransmitter glutamate, are also enriched with CNVs in people with schizophrenia. Since the GABA signaling system has strong functional links with the brain’s major excitatory system, their findings strongly indicate that a disruption of inhibitory signaling plays a role in schizophrenia. The researchers therefore conclude that faulty GABA signaling is a cause, rather than an effect, of schizophrenia.